Grey's Anatomy is a long-running medical drama series that has seen numerous characters come and go over the years. Here is a non-exhaustive list of some key characters you could expect in the series right up until 2021. **Main Characters** 1. Meredith Grey (Ellen Pompeo) 2. Alex Karev (Justin Chambers) 3. George O'Malley (T.R. Knight) 4. Izzie Stevens (Katherine Heigl) 5. Cristina Yang (Sandra Oh) 6. Richard Webber (James Pickens Jr.) 7. Miranda Bailey (Chandra Wilson) 8. Derek Shepherd (Patrick Dempsey) 9. Preston Burke (Isaiah Washington) 10. Addison Montgomery (Kate Walsh) 11. Mark Sloan (Eric Dane) 12. Lexie Grey (Chyler Leigh) 13. Owen Hunt (Kevin McKidd) 14. Arizona Robbins (Jessica Capshaw) 15. Teddy Altman (Kim Raver) 16. April Kepner (Sarah Drew) 17. Jackson Avery (Jesse Williams) 18. Amelia Shepherd (Caterina Scorsone) 19. Jo Wilson (Camilla Luddington) 20. Stephanie Edwards (Jerrika Hinton) 21. Leah Murphy (Tessa Ferrer) 22. Heather Brooks (Tina Majorino) 23. Shane Ross (Gaius Charles) 24. Maggie Pierce (Kelly McCreary) 25. Andrew DeLuca (Giacomo Gianniotti) 26. Ben Warren (Jason Winston George) 27. Nathan Riggs (Martin Henderson) 28. Atticus Lincoln "Link" (Chris Carmack) 29. Tom Koracick (Greg Germann) 30. Levi Schmitt (Jake Borelli) 31. Nico Kim (Alex Landi) **Recurring Characters** 1. Ellis Grey (Kate Burton) 2. Adele Webber (Loretta Devine) 3. Denny Duquette (Jeffrey Dean Morgan) 4. Callie Torres (Sara Ramirez) 5. Erica Hahn (Brooke Smith) 6. Sadie Harris (Melissa George) 7. Thatcher Grey (Jeff Perry) 8. Reed Adamson (Nora Zehetner) 9. Charles Percy (Robert Baker) **Guest Current/Past Characters** 1. Zola Grey Shepherd (Aniela Gumbs) 2. Carina DeLuca (Stefania Spampinato) 3. Marie Cerone (Rachel Ticotin) 4. Hayes (Richard Flood) This is by no means a complete list, as Grey's Anatomy has had hundreds of characters appear over its (currently) 17 seasons. The list also doesn't include the numerous patients, family members, and medical professionals who have shown up for brief arcs or single episodes.