Grey's Anatomy is well known for its emotional, tear-jerking episodes across its many seasons. However, the tag of the "most emotional episode" depends on individual sentiment and connection with characters. There are a number of contender episodes which are frequently mentioned by fans: 1. **"Flight" (Season 8, Episode 24)**: This season finale is often mentioned by fans as the most emotional episode. It involves a plane crash involving Meredith, Derek, Mark, Lexie, Cristina, and Arizona. Sadly, this accident ultimately leads to the death of one of the main characters, Lexie Grey. 2. **"Death and All His Friends" (Season 6, Episode 24)**: Also known as the Shooting episode, this one is particularly intense. It sees a grief-stricken widower roaming the hospital and shooting several main characters, leading to tense and heartbreaking scenes. 3. **"How to Save a Life" (Season 11, Episode 21)**: This episode deals with Derek's death, a drastic narrative turn that left many fans emotional. 4. **"Drowning on Dry Land" (Season 3, Episode 16)**: This episode marked a significant turning point for Meredith's character as she literally and metaphorically drowns, leading to emotional interactions with other key characters in a liminal space between life and death. By rewatching these, or watching them for the first time, fans and new viewers can decide for themselves which Grey's Anatomy episode they find to be the most emotional. Remember, these episodes may be intense for some viewers due to the content, which includes graphic medical scenes and potentially upsetting narrative elements.