"Grey's Anatomy," known for its dramatic twists and emotionally charged storylines, has had its fair share of shocking character departures throughout its long run. Here’s a list of some of the most impactful and stunning deaths that have occurred on the show: 1. **Dr. George O'Malley (T.R. Knight)**: The end of Season 5 packed a shocking reveal when it turned out that George, an original and beloved intern, was the John Doe hit by a bus, who later died during surgery. 2. **Dr. Lexie Grey (Chyler Leigh)**: In the Season 8 finale, the plane crash that stranded the surgeons in the wilderness claimed Lexie’s life, leaving fans and her on-screen sister Meredith devastated. 3. **Dr. Mark Sloan (Eric Dane)**: After surviving the initial plane crash and recovering in the first few episodes of Season 9, Mark succumbs to his injuries, leading to a farewell via a series of flashbacks. 4. **Dr. Derek Shepherd (Patrick Dempsey)**: Perhaps one of the most shocking deaths was that of Derek, also known as "McDreamy," who died after being hit by a truck in Season 11, despite seeming to have initially survived the accident. 5. **Dr. Reed Adamson (Nora Zehetner) and Dr. Charles Percy (Robert Baker)**: Both surgeons were killed during the hospital shooting rampage in the Season 6 finale, which was an intense and traumatic event in Grey’s Anatomy history. 6. **Dr. Lexie Grey (Chyler Leigh)**: The Season 8 finale brought another heartbreak with the sudden death of Lexie in the tragic plane crash, which profoundly affected all the other characters, especially Mark Sloan and Meredith Grey. 7. **Dr. Heather Brooks (Tina Majorino)**: Her untimely death in the Season 10 premiere was a shock to fans after she was electrocuted and fell into a coma, from which she never recovered. 8. **Dr. Andrew DeLuca (Giacomo Gianniotti)**: DeLuca’s death in Season 17 caught viewers off guard as he succumbed to stab wounds sustained while trying to take down a sex trafficker. 9. **Dr. Samuel Norbert Avery (the baby of Jackson Avery and April Kepner)**: This heartbreaking storyline in Season 11, where the baby suffers from osteogenesis imperfecta and dies shortly after birth, deeply affected not only the characters but also the audience. 10. **Dr. Adele Webber (Loretta Devine)**: Adele, the wife of Chief Richard Webber, dies of a heart attack after a long battle with Alzheimer's. Her death was particularly poignant as it occurred right as Richard was performing at Bailey's wedding. 11. **Dr. Ellis Grey (Kate Burton)**: While she had been suffering from Alzheimer's for the duration of her time on the show, the death of Meredith's mother still packed an emotional punch due to the complex relationship between the two. These deaths often serve not only to evoke an emotional response from the viewers but also to drive character growth and narrative development. Each one has marked a significant change in the dynamics of the show and continues to be remembered as a defining moment in "Grey’s Anatomy" history.